AFC South
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) | 09/13/2026 01:00 PM EDT | New York Jets | Tennessee Titans | Nissan Stadium | |
| Regular season (Week 2) | 09/20/2026 01:00 PM EDT | Philadelphia Eagles | Tennessee Titans | Nissan Stadium | |
| Regular season (Week 3) | 09/27/2026 01:00 PM EDT | Tennessee Titans | New York Giants | MetLife Stadium | |
| Regular season (Week 4) | 10/04/2026 01:00 PM EDT | Tennessee Titans | Baltimore Ravens | M&T Bank Stadium | |
| Regular season (Week 5) | 10/11/2026 01:00 PM EDT | Houston Texans | Tennessee Titans | Nissan Stadium | |
| Regular season (Week 6) | 10/18/2026 01:00 PM EDT | Tennessee Titans | Indianapolis Colts | Lucas Oil Stadium | |
| Regular season (Week 7) | 10/25/2026 01:00 PM EDT | Cleveland Browns | Tennessee Titans | Nissan Stadium | |
| Regular season (Week 8) | 11/01/2026 01:00 PM EST | Tennessee Titans | Cincinnati Bengals | Paycor Stadium | |
| Regular season (Week 10) | 11/15/2026 01:00 PM EST | Jacksonville Jaguars | Tennessee Titans | Nissan Stadium | |
| Regular season (Week 11) | 11/22/2026 01:00 PM EST | Tennessee Titans | Dallas Cowboys | AT&T Stadium | |
| Regular season (Week 12) | 11/29/2026 04:05 PM EST | Tennessee Titans | Jacksonville Jaguars | EverBank Stadium | |
| Regular season (Week 13) | 12/06/2026 01:00 PM EST | Washington Commanders | Tennessee Titans | Nissan Stadium | |
| Regular season (Week 14) | 12/13/2026 01:00 PM EST | Tennessee Titans | Detroit Lions | Ford Field | |
| Regular season (Week 15) | 12/20/2026 01:00 PM EST | Indianapolis Colts | Tennessee Titans | Nissan Stadium | |
| Regular season (Week 16) | 12/27/2026 04:05 PM EST | Tennessee Titans | Las Vegas Raiders | Allegiant Stadium | |
| Regular season (Week 17) | 01/03/2027 01:00 PM EST | Pittsburgh Steelers | Tennessee Titans | Nissan Stadium | |
| Regular season (Week 18) | 01/10/2027 01:00 PM EST | Tennessee Titans | Houston Texans | Reliant Stadium |