NFC West
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) |
Thursday 09/10/2026 8:35 PM EDT |
San Francisco 49ers | Los Angeles Rams | Melbourne Cricket Ground | 27 : 7 |
| Regular season (Week 2) |
Sunday 09/20/2026 4:25 PM EDT |
Miami Dolphins | San Francisco 49ers | Levi's Stadium | 13 : 35 |
| Regular season (Week 3) |
Sunday 09/27/2026 4:05 PM EDT |
Arizona Cardinals | San Francisco 49ers | Levi's Stadium | 30 : 36 |
| Regular season (Week 4) |
Sunday 10/04/2026 4:25 PM EDT |
Denver Broncos | San Francisco 49ers | Levi's Stadium | 14 : 24 |
| Regular season (Week 5) |
Sunday 10/11/2026 4:25 PM EDT |
San Francisco 49ers | Seattle Seahawks | Lumen Field | 32 : 29 |
| Regular season (Week 6) |
Monday 10/19/2026 8:15 PM EDT |
Washington Commanders | San Francisco 49ers | Levi's Stadium | 17 : 23 |
| Regular season (Week 7) |
Sunday 10/25/2026 1:00 PM EDT |
San Francisco 49ers | Atlanta Falcons | Mercedes-Benz Stadium | 20 : 29 |
| Regular season (Week 9) |
Sunday 11/08/2026 4:05 PM EST |
Las Vegas Raiders | San Francisco 49ers | Levi's Stadium | |
| Regular season (Week 10) |
Sunday 11/15/2026 4:25 PM EST |
San Francisco 49ers | Dallas Cowboys | AT&T Stadium | |
| Regular season (Week 11) |
Sunday 11/22/2026 8:20 PM EST |
Minnesota Vikings | San Francisco 49ers | Estadio Banorte | |
| Regular season (Week 12) |
Sunday 11/29/2026 4:25 PM EST |
Seattle Seahawks | San Francisco 49ers | Levi's Stadium | |
| Regular season (Week 13) |
Sunday 12/06/2026 1:00 PM EST |
San Francisco 49ers | New York Giants | MetLife Stadium | |
| Regular season (Week 14) |
Sunday 12/13/2026 4:25 PM EST |
Los Angeles Rams | San Francisco 49ers | Levi's Stadium | |
| Regular season (Week 15) |
Thursday 12/17/2026 8:15 PM EST |
San Francisco 49ers | Los Angeles Chargers | SoFi Stadium | |
| Regular season (Week 16) |
Sunday 12/27/2026 4:25 PM EST |
San Francisco 49ers | Kansas City Chiefs | GEHA Field at Arrowhead Stadium | |
| Regular season (Week 17) |
Sunday 01/03/2027 8:20 PM EST |
Philadelphia Eagles | San Francisco 49ers | Levi's Stadium | |
| Regular season (Week 18) |
Sunday 01/10/2027 1:00 PM EST |
San Francisco 49ers | Arizona Cardinals | State Farm Stadium |