NFC West
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) | 09/10/2026 08:35 PM EDT | San Francisco 49ers | Los Angeles Rams | Melbourne Cricket Ground | |
| Regular season (Week 2) | 09/20/2026 04:25 PM EDT | Miami Dolphins | San Francisco 49ers | Levi's Stadium | |
| Regular season (Week 3) | 09/27/2026 04:05 PM EDT | Arizona Cardinals | San Francisco 49ers | Levi's Stadium | |
| Regular season (Week 4) | 10/04/2026 04:25 PM EDT | Denver Broncos | San Francisco 49ers | Levi's Stadium | |
| Regular season (Week 5) | 10/11/2026 04:25 PM EDT | San Francisco 49ers | Seattle Seahawks | Lumen Field | |
| Regular season (Week 6) | 10/19/2026 08:15 PM EDT | Washington Commanders | San Francisco 49ers | Levi's Stadium | |
| Regular season (Week 7) | 10/25/2026 01:00 PM EDT | San Francisco 49ers | Atlanta Falcons | Mercedes-Benz Stadium | |
| Regular season (Week 9) | 11/08/2026 04:05 PM EST | Las Vegas Raiders | San Francisco 49ers | Levi's Stadium | |
| Regular season (Week 10) | 11/15/2026 04:25 PM EST | San Francisco 49ers | Dallas Cowboys | AT&T Stadium | |
| Regular season (Week 11) | 11/22/2026 08:20 PM EST | Minnesota Vikings | San Francisco 49ers | Estadio Banorte | |
| Regular season (Week 12) | 11/29/2026 04:25 PM EST | Seattle Seahawks | San Francisco 49ers | Levi's Stadium | |
| Regular season (Week 13) | 12/06/2026 01:00 PM EST | San Francisco 49ers | New York Giants | MetLife Stadium | |
| Regular season (Week 14) | 12/13/2026 04:25 PM EST | Los Angeles Rams | San Francisco 49ers | Levi's Stadium | |
| Regular season (Week 15) | 12/17/2026 08:15 PM EST | San Francisco 49ers | Los Angeles Chargers | SoFi Stadium | |
| Regular season (Week 16) | 12/27/2026 04:25 PM EST | San Francisco 49ers | Kansas City Chiefs | GEHA Field at Arrowhead Stadium | |
| Regular season (Week 17) | 01/03/2027 08:20 PM EST | Philadelphia Eagles | San Francisco 49ers | Levi's Stadium | |
| Regular season (Week 18) | 01/10/2027 01:00 PM EST | San Francisco 49ers | Arizona Cardinals | State Farm Stadium |