AFC North
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) | 09/13/2026 01:00 PM EDT | Atlanta Falcons | Pittsburgh Steelers | Acrisure Stadium | |
| Regular season (Week 2) | 09/20/2026 01:00 PM EDT | Pittsburgh Steelers | New England Patriots | Gillette Stadium | |
| Regular season (Week 3) | 09/27/2026 01:00 PM EDT | Cincinnati Bengals | Pittsburgh Steelers | Acrisure Stadium | |
| Regular season (Week 4) | 10/01/2026 08:15 PM EDT | Pittsburgh Steelers | Cleveland Browns | Huntington Bank Field | |
| Regular season (Week 5) | 10/11/2026 01:00 PM EDT | Indianapolis Colts | Pittsburgh Steelers | Acrisure Stadium | |
| Regular season (Week 6) | 10/18/2026 01:00 PM EDT | Pittsburgh Steelers | Tampa Bay Buccaneers | Raymond James Stadium | |
| Regular season (Week 7) | 10/25/2026 09:30 AM EDT | Pittsburgh Steelers | New Orleans Saints | Stade de France | |
| Regular season (Week 8) | 11/01/2026 01:00 PM EST | Cleveland Browns | Pittsburgh Steelers | Acrisure Stadium | |
| Regular season (Week 10) | 11/15/2026 08:20 PM EST | Pittsburgh Steelers | Cincinnati Bengals | Paycor Stadium | |
| Regular season (Week 11) | 11/22/2026 04:25 PM EST | Pittsburgh Steelers | Philadelphia Eagles | Lincoln Financial Field | |
| Regular season (Week 12) | 11/27/2026 03:00 PM EST | Denver Broncos | Pittsburgh Steelers | Acrisure Stadium | |
| Regular season (Week 13) | 12/06/2026 08:20 PM EST | Houston Texans | Pittsburgh Steelers | Acrisure Stadium | |
| Regular season (Week 14) | 12/14/2026 08:15 PM EST | Pittsburgh Steelers | Jacksonville Jaguars | EverBank Stadium | |
| Regular season (Week 15) | 12/20/2026 01:00 PM EST | Baltimore Ravens | Pittsburgh Steelers | Acrisure Stadium | |
| Regular season (Week 16) | 12/27/2026 01:00 PM EST | Carolina Panthers | Pittsburgh Steelers | Acrisure Stadium | |
| Regular season (Week 17) | 01/03/2027 01:00 PM EST | Pittsburgh Steelers | Tennessee Titans | Nissan Stadium | |
| Regular season (Week 18) | 01/10/2027 01:00 PM EST | Pittsburgh Steelers | Baltimore Ravens | M&T Bank Stadium |