NFC South
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) | 09/13/2026 01:00 PM EDT | New Orleans Saints | Detroit Lions | Ford Field | |
| Regular season (Week 2) | 09/20/2026 01:00 PM EDT | New Orleans Saints | Baltimore Ravens | M&T Bank Stadium | |
| Regular season (Week 3) | 09/27/2026 04:25 PM EDT | Las Vegas Raiders | New Orleans Saints | Caesars Superdome | |
| Regular season (Week 4) | 10/05/2026 08:15 PM EDT | Atlanta Falcons | New Orleans Saints | Caesars Superdome | |
| Regular season (Week 5) | 10/11/2026 01:00 PM EDT | Minnesota Vikings | New Orleans Saints | Caesars Superdome | |
| Regular season (Week 6) | 10/18/2026 01:00 PM EDT | New Orleans Saints | New York Giants | MetLife Stadium | |
| Regular season (Week 7) | 10/25/2026 09:30 AM EDT | Pittsburgh Steelers | New Orleans Saints | Stade de France | |
| Regular season (Week 9) | 11/08/2026 01:00 PM EST | Cleveland Browns | New Orleans Saints | Caesars Superdome | |
| Regular season (Week 10) | 11/15/2026 01:00 PM EST | Carolina Panthers | New Orleans Saints | Caesars Superdome | |
| Regular season (Week 11) | 11/22/2026 01:00 PM EST | New Orleans Saints | Chicago Bears | Soldier Field | |
| Regular season (Week 12) | 11/29/2026 01:00 PM EST | New Orleans Saints | Cincinnati Bengals | Paycor Stadium | |
| Regular season (Week 13) | 12/06/2026 01:00 PM EST | Green Bay Packers | New Orleans Saints | Caesars Superdome | |
| Regular season (Week 14) | 12/13/2026 01:00 PM EST | New Orleans Saints | Carolina Panthers | Bank of America Stadium | |
| Regular season (Week 15) | 12/20/2026 01:00 PM EST | New Orleans Saints | Tampa Bay Buccaneers | Raymond James Stadium | |
| Regular season (Week 16) | 12/27/2026 01:00 PM EST | Arizona Cardinals | New Orleans Saints | Caesars Superdome | |
| Regular season (Week 17) | 01/03/2027 01:00 PM EST | New Orleans Saints | Atlanta Falcons | Mercedes-Benz Stadium | |
| Regular season (Week 18) | 01/10/2027 01:00 PM EST | Tampa Bay Buccaneers | New Orleans Saints | Caesars Superdome |