AFC East
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) | 09/09/2026 08:20 PM EDT | New England Patriots | Seattle Seahawks | Lumen Field | |
| Regular season (Week 2) | 09/20/2026 01:00 PM EDT | Pittsburgh Steelers | New England Patriots | Gillette Stadium | |
| Regular season (Week 3) | 09/27/2026 01:00 PM EDT | New England Patriots | Jacksonville Jaguars | EverBank Stadium | |
| Regular season (Week 4) | 10/04/2026 01:00 PM EDT | New England Patriots | Buffalo Bills | Highmark Stadium | |
| Regular season (Week 5) | 10/11/2026 01:00 PM EDT | Las Vegas Raiders | New England Patriots | Gillette Stadium | |
| Regular season (Week 6) | 10/18/2026 01:00 PM EDT | New York Jets | New England Patriots | Gillette Stadium | |
| Regular season (Week 7) | 10/22/2026 08:15 PM EDT | New England Patriots | Chicago Bears | Soldier Field | |
| Regular season (Week 8) | 11/01/2026 04:25 PM EST | New England Patriots | Miami Dolphins | Hard Rock Stadium | |
| Regular season (Week 9) | 11/08/2026 04:25 PM EST | Green Bay Packers | New England Patriots | Gillette Stadium | |
| Regular season (Week 10) | 11/15/2026 09:30 AM EST | New England Patriots | Detroit Lions | FC Bayern Munich Stadium | |
| Regular season (Week 12) | 11/29/2026 08:20 PM EST | New England Patriots | Los Angeles Chargers | SoFi Stadium | |
| Regular season (Week 13) | 12/06/2026 04:25 PM EST | Buffalo Bills | New England Patriots | Gillette Stadium | |
| Regular season (Week 14) | 12/10/2026 08:15 PM EST | Minnesota Vikings | New England Patriots | Gillette Stadium | |
| Regular season (Week 15) | 12/21/2026 08:15 PM EST | New England Patriots | Kansas City Chiefs | GEHA Field at Arrowhead Stadium | |
| Regular season (Week 16) | 12/27/2026 01:00 PM EST | New England Patriots | New York Jets | MetLife Stadium | |
| Regular season (Week 17) | 01/03/2027 01:00 PM EST | Denver Broncos | New England Patriots | Gillette Stadium | |
| Regular season (Week 18) | 01/10/2027 01:00 PM EST | Miami Dolphins | New England Patriots | Gillette Stadium |