AFC West
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) | 09/13/2026 04:25 PM EDT | Arizona Cardinals | Los Angeles Chargers | SoFi Stadium | |
| Regular season (Week 2) | 09/20/2026 04:05 PM EDT | Las Vegas Raiders | Los Angeles Chargers | SoFi Stadium | |
| Regular season (Week 3) | 09/27/2026 01:00 PM EDT | Los Angeles Chargers | Buffalo Bills | Highmark Stadium | |
| Regular season (Week 4) | 10/04/2026 04:25 PM EDT | Los Angeles Chargers | Seattle Seahawks | Lumen Field | |
| Regular season (Week 5) | 10/11/2026 04:05 PM EDT | Denver Broncos | Los Angeles Chargers | SoFi Stadium | |
| Regular season (Week 6) | 10/18/2026 04:25 PM EDT | Los Angeles Chargers | Kansas City Chiefs | GEHA Field at Arrowhead Stadium | |
| Regular season (Week 8) | 11/01/2026 04:05 PM EST | Los Angeles Chargers | Los Angeles Rams | SoFi Stadium | |
| Regular season (Week 9) | 11/08/2026 04:05 PM EST | Houston Texans | Los Angeles Chargers | SoFi Stadium | |
| Regular season (Week 10) | 11/16/2026 08:15 PM EST | Los Angeles Chargers | Baltimore Ravens | M&T Bank Stadium | |
| Regular season (Week 11) | 11/22/2026 04:05 PM EST | New York Jets | Los Angeles Chargers | SoFi Stadium | |
| Regular season (Week 12) | 11/29/2026 08:20 PM EST | New England Patriots | Los Angeles Chargers | SoFi Stadium | |
| Regular season (Week 13) | 12/06/2026 01:00 PM EST | Los Angeles Chargers | Tampa Bay Buccaneers | Raymond James Stadium | |
| Regular season (Week 14) | 12/13/2026 04:05 PM EST | Los Angeles Chargers | Las Vegas Raiders | Allegiant Stadium | |
| Regular season (Week 15) | 12/17/2026 08:15 PM EST | San Francisco 49ers | Los Angeles Chargers | SoFi Stadium | |
| Regular season (Week 16) | 12/27/2026 01:00 PM EST | Los Angeles Chargers | Miami Dolphins | Hard Rock Stadium | |
| Regular season (Week 17) | 01/03/2027 01:00 PM EST | Kansas City Chiefs | Los Angeles Chargers | SoFi Stadium | |
| Regular season (Week 18) | 01/10/2027 01:00 PM EST | Los Angeles Chargers | Denver Broncos | Empower Field at Mile High |