AFC West
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) | 09/14/2026 08:15 PM EDT | Denver Broncos | Kansas City Chiefs | GEHA Field at Arrowhead Stadium | |
| Regular season (Week 2) | 09/20/2026 08:20 PM EDT | Indianapolis Colts | Kansas City Chiefs | GEHA Field at Arrowhead Stadium | |
| Regular season (Week 3) | 09/27/2026 01:00 PM EDT | Kansas City Chiefs | Miami Dolphins | Hard Rock Stadium | |
| Regular season (Week 4) | 10/04/2026 04:25 PM EDT | Kansas City Chiefs | Las Vegas Raiders | Allegiant Stadium | |
| Regular season (Week 6) | 10/18/2026 04:25 PM EDT | Los Angeles Chargers | Kansas City Chiefs | GEHA Field at Arrowhead Stadium | |
| Regular season (Week 7) | 10/25/2026 08:20 PM EDT | Kansas City Chiefs | Seattle Seahawks | Lumen Field | |
| Regular season (Week 8) | 11/01/2026 04:25 PM EST | Kansas City Chiefs | Denver Broncos | Empower Field at Mile High | |
| Regular season (Week 9) | 11/08/2026 01:00 PM EST | New York Jets | Kansas City Chiefs | GEHA Field at Arrowhead Stadium | |
| Regular season (Week 10) | 11/15/2026 01:00 PM EST | Kansas City Chiefs | Atlanta Falcons | Mercedes-Benz Stadium | |
| Regular season (Week 11) | 11/22/2026 01:00 PM EST | Arizona Cardinals | Kansas City Chiefs | GEHA Field at Arrowhead Stadium | |
| Regular season (Week 12) | 11/26/2026 08:20 PM EST | Kansas City Chiefs | Buffalo Bills | Highmark Stadium | |
| Regular season (Week 13) | 12/03/2026 08:15 PM EST | Kansas City Chiefs | Los Angeles Rams | SoFi Stadium | |
| Regular season (Week 14) | 12/13/2026 04:25 PM EST | Kansas City Chiefs | Cincinnati Bengals | Paycor Stadium | |
| Regular season (Week 15) | 12/21/2026 08:15 PM EST | New England Patriots | Kansas City Chiefs | GEHA Field at Arrowhead Stadium | |
| Regular season (Week 16) | 12/27/2026 04:25 PM EST | San Francisco 49ers | Kansas City Chiefs | GEHA Field at Arrowhead Stadium | |
| Regular season (Week 17) | 01/03/2027 01:00 PM EST | Kansas City Chiefs | Los Angeles Chargers | SoFi Stadium | |
| Regular season (Week 18) | 01/10/2027 01:00 PM EST | Las Vegas Raiders | Kansas City Chiefs | GEHA Field at Arrowhead Stadium |