AFC South
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) |
Sunday 09/13/2026 1:00 PM EDT |
Cleveland Browns | Jacksonville Jaguars | EverBank Stadium | 10 : 34 |
| Regular season (Week 2) |
Sunday 09/20/2026 4:05 PM EDT |
Jacksonville Jaguars | Denver Broncos | Empower Field at Mile High | 13 : 20 |
| Regular season (Week 3) |
Sunday 09/27/2026 1:00 PM EDT |
New England Patriots | Jacksonville Jaguars | EverBank Stadium | 6 : 35 |
| Regular season (Week 4) |
Sunday 10/04/2026 1:00 PM EDT |
Jacksonville Jaguars | Cincinnati Bengals | Paycor Stadium | 22 : 17 |
| Regular season (Week 5) |
Sunday 10/11/2026 9:30 AM EDT |
Philadelphia Eagles | Jacksonville Jaguars | Tottenham Hotspur Stadium | 17 : 19 |
| Regular season (Week 6) |
Sunday 10/18/2026 9:30 AM EDT |
Houston Texans | Jacksonville Jaguars | Wembley Stadium | 34 : 31 |
| Regular season (Week 8) |
Sunday 11/01/2026 1:00 PM EST |
Indianapolis Colts | Jacksonville Jaguars | EverBank Stadium | |
| Regular season (Week 9) |
Thursday 11/05/2026 8:15 PM EST |
Jacksonville Jaguars | Baltimore Ravens | M&T Bank Stadium | |
| Regular season (Week 10) |
Sunday 11/15/2026 1:00 PM EST |
Jacksonville Jaguars | Tennessee Titans | Nissan Stadium | |
| Regular season (Week 11) |
Sunday 11/22/2026 1:00 PM EST |
Jacksonville Jaguars | New York Giants | MetLife Stadium | |
| Regular season (Week 12) |
Sunday 11/29/2026 4:05 PM EST |
Tennessee Titans | Jacksonville Jaguars | EverBank Stadium | |
| Regular season (Week 13) |
Sunday 12/06/2026 1:00 PM EST |
Jacksonville Jaguars | Chicago Bears | Soldier Field | |
| Regular season (Week 14) |
Monday 12/14/2026 8:15 PM EST |
Pittsburgh Steelers | Jacksonville Jaguars | EverBank Stadium | |
| Regular season (Week 15) |
Sunday 12/20/2026 1:00 PM EST |
Jacksonville Jaguars | Houston Texans | Reliant Stadium | |
| Regular season (Week 16) |
Sunday 12/27/2026 8:20 PM EST |
Jacksonville Jaguars | Dallas Cowboys | AT&T Stadium | |
| Regular season (Week 17) |
Sunday 01/03/2027 1:00 PM EST |
Washington Commanders | Jacksonville Jaguars | EverBank Stadium | |
| Regular season (Week 18) |
Sunday 01/10/2027 1:00 PM EST |
Jacksonville Jaguars | Indianapolis Colts | Lucas Oil Stadium |