AFC South
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) | 09/13/2026 01:00 PM EDT | Cleveland Browns | Jacksonville Jaguars | EverBank Stadium | |
| Regular season (Week 2) | 09/20/2026 04:05 PM EDT | Jacksonville Jaguars | Denver Broncos | Empower Field at Mile High | |
| Regular season (Week 3) | 09/27/2026 01:00 PM EDT | New England Patriots | Jacksonville Jaguars | EverBank Stadium | |
| Regular season (Week 4) | 10/04/2026 01:00 PM EDT | Jacksonville Jaguars | Cincinnati Bengals | Paycor Stadium | |
| Regular season (Week 5) | 10/11/2026 09:30 AM EDT | Philadelphia Eagles | Jacksonville Jaguars | Tottenham Hotspur Stadium | |
| Regular season (Week 6) | 10/18/2026 09:30 AM EDT | Houston Texans | Jacksonville Jaguars | Wembley Stadium | |
| Regular season (Week 8) | 11/01/2026 01:00 PM EST | Indianapolis Colts | Jacksonville Jaguars | EverBank Stadium | |
| Regular season (Week 9) | 11/05/2026 08:15 PM EST | Jacksonville Jaguars | Baltimore Ravens | M&T Bank Stadium | |
| Regular season (Week 10) | 11/15/2026 01:00 PM EST | Jacksonville Jaguars | Tennessee Titans | Nissan Stadium | |
| Regular season (Week 11) | 11/22/2026 01:00 PM EST | Jacksonville Jaguars | New York Giants | MetLife Stadium | |
| Regular season (Week 12) | 11/29/2026 04:05 PM EST | Tennessee Titans | Jacksonville Jaguars | EverBank Stadium | |
| Regular season (Week 13) | 12/06/2026 01:00 PM EST | Jacksonville Jaguars | Chicago Bears | Soldier Field | |
| Regular season (Week 14) | 12/14/2026 08:15 PM EST | Pittsburgh Steelers | Jacksonville Jaguars | EverBank Stadium | |
| Regular season (Week 15) | 12/20/2026 01:00 PM EST | Jacksonville Jaguars | Houston Texans | Reliant Stadium | |
| Regular season (Week 16) | 12/27/2026 08:20 PM EST | Jacksonville Jaguars | Dallas Cowboys | AT&T Stadium | |
| Regular season (Week 17) | 01/03/2027 01:00 PM EST | Washington Commanders | Jacksonville Jaguars | EverBank Stadium | |
| Regular season (Week 18) | 01/10/2027 01:00 PM EST | Jacksonville Jaguars | Indianapolis Colts | Lucas Oil Stadium |