AFC South
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) |
Sunday 09/13/2026 1:00 PM EDT |
Baltimore Ravens | Indianapolis Colts | Lucas Oil Stadium | 41 : 23 |
| Regular season (Week 2) |
Sunday 09/20/2026 8:20 PM EDT |
Indianapolis Colts | Kansas City Chiefs | GEHA Field at Arrowhead Stadium | 30 : 33 |
| Regular season (Week 3) |
Sunday 09/27/2026 1:00 PM EDT |
Houston Texans | Indianapolis Colts | Lucas Oil Stadium | 17 : 19 |
| Regular season (Week 4) |
Sunday 10/04/2026 9:30 AM EDT |
Indianapolis Colts | Washington Commanders | Tottenham Hotspur Stadium | 30 : 13 |
| Regular season (Week 5) |
Sunday 10/11/2026 1:00 PM EDT |
Indianapolis Colts | Pittsburgh Steelers | Acrisure Stadium | 22 : 34 |
| Regular season (Week 6) |
Sunday 10/18/2026 1:00 PM EDT |
Tennessee Titans | Indianapolis Colts | Lucas Oil Stadium | 26 : 20 |
| Regular season (Week 7) |
Sunday 10/25/2026 1:00 PM EDT |
Indianapolis Colts | Minnesota Vikings | U.S. Bank Stadium | 10 : 16 |
| Regular season (Week 8) |
Sunday 11/01/2026 1:00 PM EST |
Indianapolis Colts | Jacksonville Jaguars | EverBank Stadium | |
| Regular season (Week 9) |
Sunday 11/08/2026 1:00 PM EST |
Dallas Cowboys | Indianapolis Colts | Lucas Oil Stadium | |
| Regular season (Week 10) |
Sunday 11/15/2026 1:00 PM EST |
Miami Dolphins | Indianapolis Colts | Lucas Oil Stadium | |
| Regular season (Week 11) |
Thursday 11/19/2026 8:15 PM EST |
Indianapolis Colts | Houston Texans | Reliant Stadium | |
| Regular season (Week 12) |
Sunday 11/29/2026 1:00 PM EST |
New York Giants | Indianapolis Colts | Lucas Oil Stadium | |
| Regular season (Week 14) |
Sunday 12/13/2026 1:00 PM EST |
Indianapolis Colts | Philadelphia Eagles | Lincoln Financial Field | |
| Regular season (Week 15) |
Sunday 12/20/2026 1:00 PM EST |
Indianapolis Colts | Tennessee Titans | Nissan Stadium | |
| Regular season (Week 16) |
Sunday 12/27/2026 1:00 PM EST |
Cincinnati Bengals | Indianapolis Colts | Lucas Oil Stadium | |
| Regular season (Week 17) |
Sunday 01/03/2027 1:00 PM EST |
Indianapolis Colts | Cleveland Browns | Huntington Bank Field | |
| Regular season (Week 18) |
Sunday 01/10/2027 1:00 PM EST |
Jacksonville Jaguars | Indianapolis Colts | Lucas Oil Stadium |