AFC South
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) | 09/13/2026 01:00 PM EDT | Baltimore Ravens | Indianapolis Colts | Lucas Oil Stadium | |
| Regular season (Week 2) | 09/20/2026 08:20 PM EDT | Indianapolis Colts | Kansas City Chiefs | GEHA Field at Arrowhead Stadium | |
| Regular season (Week 3) | 09/27/2026 01:00 PM EDT | Houston Texans | Indianapolis Colts | Lucas Oil Stadium | |
| Regular season (Week 4) | 10/04/2026 09:30 AM EDT | Indianapolis Colts | Washington Commanders | Tottenham Hotspur Stadium | |
| Regular season (Week 5) | 10/11/2026 01:00 PM EDT | Indianapolis Colts | Pittsburgh Steelers | Acrisure Stadium | |
| Regular season (Week 6) | 10/18/2026 01:00 PM EDT | Tennessee Titans | Indianapolis Colts | Lucas Oil Stadium | |
| Regular season (Week 7) | 10/25/2026 01:00 PM EDT | Indianapolis Colts | Minnesota Vikings | U.S. Bank Stadium | |
| Regular season (Week 8) | 11/01/2026 01:00 PM EST | Indianapolis Colts | Jacksonville Jaguars | EverBank Stadium | |
| Regular season (Week 9) | 11/08/2026 01:00 PM EST | Dallas Cowboys | Indianapolis Colts | Lucas Oil Stadium | |
| Regular season (Week 10) | 11/15/2026 01:00 PM EST | Miami Dolphins | Indianapolis Colts | Lucas Oil Stadium | |
| Regular season (Week 11) | 11/19/2026 08:15 PM EST | Indianapolis Colts | Houston Texans | Reliant Stadium | |
| Regular season (Week 12) | 11/29/2026 01:00 PM EST | New York Giants | Indianapolis Colts | Lucas Oil Stadium | |
| Regular season (Week 14) | 12/13/2026 01:00 PM EST | Indianapolis Colts | Philadelphia Eagles | Lincoln Financial Field | |
| Regular season (Week 15) | 12/20/2026 01:00 PM EST | Indianapolis Colts | Tennessee Titans | Nissan Stadium | |
| Regular season (Week 16) | 12/27/2026 01:00 PM EST | Cincinnati Bengals | Indianapolis Colts | Lucas Oil Stadium | |
| Regular season (Week 17) | 01/03/2027 01:00 PM EST | Indianapolis Colts | Cleveland Browns | Huntington Bank Field | |
| Regular season (Week 18) | 01/10/2027 01:00 PM EST | Jacksonville Jaguars | Indianapolis Colts | Lucas Oil Stadium |