AFC South
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) | 09/13/2026 01:00 PM EDT | Buffalo Bills | Houston Texans | Reliant Stadium | |
| Regular season (Week 2) | 09/20/2026 01:00 PM EDT | Cincinnati Bengals | Houston Texans | Reliant Stadium | |
| Regular season (Week 3) | 09/27/2026 01:00 PM EDT | Houston Texans | Indianapolis Colts | Lucas Oil Stadium | |
| Regular season (Week 4) | 10/04/2026 01:00 PM EDT | Dallas Cowboys | Houston Texans | Reliant Stadium | |
| Regular season (Week 5) | 10/11/2026 01:00 PM EDT | Houston Texans | Tennessee Titans | Nissan Stadium | |
| Regular season (Week 6) | 10/18/2026 09:30 AM EDT | Houston Texans | Jacksonville Jaguars | Wembley Stadium | |
| Regular season (Week 7) | 10/25/2026 01:00 PM EDT | New York Giants | Houston Texans | Reliant Stadium | |
| Regular season (Week 9) | 11/08/2026 04:05 PM EST | Houston Texans | Los Angeles Chargers | SoFi Stadium | |
| Regular season (Week 10) | 11/15/2026 01:00 PM EST | Houston Texans | Cleveland Browns | Huntington Bank Field | |
| Regular season (Week 11) | 11/19/2026 08:15 PM EST | Indianapolis Colts | Houston Texans | Reliant Stadium | |
| Regular season (Week 12) | 11/29/2026 01:00 PM EST | Baltimore Ravens | Houston Texans | Reliant Stadium | |
| Regular season (Week 13) | 12/06/2026 08:20 PM EST | Houston Texans | Pittsburgh Steelers | Acrisure Stadium | |
| Regular season (Week 14) | 12/13/2026 01:00 PM EST | Houston Texans | Washington Commanders | Northwest Stadium | |
| Regular season (Week 15) | 12/20/2026 01:00 PM EST | Jacksonville Jaguars | Houston Texans | Reliant Stadium | |
| Regular season (Week 16) | 12/24/2026 08:15 PM EST | Houston Texans | Philadelphia Eagles | Lincoln Financial Field | |
| Regular season (Week 17) | 01/04/2027 08:15 PM EST | Houston Texans | Green Bay Packers | Lambeau Field | |
| Regular season (Week 18) | 01/10/2027 01:00 PM EST | Tennessee Titans | Houston Texans | Reliant Stadium |