AFC South
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) |
Sunday 09/13/2026 1:00 PM EDT |
Buffalo Bills | Houston Texans | Reliant Stadium | 36 : 31 |
| Regular season (Week 2) |
Sunday 09/20/2026 1:00 PM EDT |
Cincinnati Bengals | Houston Texans | Reliant Stadium | 20 : 6 |
| Regular season (Week 3) |
Sunday 09/27/2026 1:00 PM EDT |
Houston Texans | Indianapolis Colts | Lucas Oil Stadium | 17 : 19 |
| Regular season (Week 4) |
Sunday 10/04/2026 1:00 PM EDT |
Dallas Cowboys | Houston Texans | Reliant Stadium | 34 : 30 |
| Regular season (Week 5) |
Sunday 10/11/2026 1:00 PM EDT |
Houston Texans | Tennessee Titans | Nissan Stadium | 26 : 3 |
| Regular season (Week 6) |
Sunday 10/18/2026 9:30 AM EDT |
Houston Texans | Jacksonville Jaguars | Wembley Stadium | 34 : 31 |
| Regular season (Week 7) |
Sunday 10/25/2026 1:00 PM EDT |
New York Giants | Houston Texans | Reliant Stadium | 27 : 21 |
| Regular season (Week 9) |
Sunday 11/08/2026 4:05 PM EST |
Houston Texans | Los Angeles Chargers | SoFi Stadium | |
| Regular season (Week 10) |
Sunday 11/15/2026 1:00 PM EST |
Houston Texans | Cleveland Browns | Huntington Bank Field | |
| Regular season (Week 11) |
Thursday 11/19/2026 8:15 PM EST |
Indianapolis Colts | Houston Texans | Reliant Stadium | |
| Regular season (Week 12) |
Sunday 11/29/2026 1:00 PM EST |
Baltimore Ravens | Houston Texans | Reliant Stadium | |
| Regular season (Week 13) |
Sunday 12/06/2026 8:20 PM EST |
Houston Texans | Pittsburgh Steelers | Acrisure Stadium | |
| Regular season (Week 14) |
Sunday 12/13/2026 1:00 PM EST |
Houston Texans | Washington Commanders | Northwest Stadium | |
| Regular season (Week 15) |
Sunday 12/20/2026 1:00 PM EST |
Jacksonville Jaguars | Houston Texans | Reliant Stadium | |
| Regular season (Week 16) |
Thursday 12/24/2026 8:15 PM EST |
Houston Texans | Philadelphia Eagles | Lincoln Financial Field | |
| Regular season (Week 17) |
Monday 01/04/2027 8:15 PM EST |
Houston Texans | Green Bay Packers | Lambeau Field | |
| Regular season (Week 18) |
Sunday 01/10/2027 1:00 PM EST |
Tennessee Titans | Houston Texans | Reliant Stadium |