NFC North
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) | 09/13/2026 01:00 PM EDT | New Orleans Saints | Detroit Lions | Ford Field | |
| Regular season (Week 2) | 09/17/2026 08:15 PM EDT | Detroit Lions | Buffalo Bills | Highmark Stadium | |
| Regular season (Week 3) | 09/27/2026 01:00 PM EDT | New York Jets | Detroit Lions | Ford Field | |
| Regular season (Week 4) | 10/04/2026 08:20 PM EDT | Detroit Lions | Carolina Panthers | Bank of America Stadium | |
| Regular season (Week 5) | 10/11/2026 04:25 PM EDT | Detroit Lions | Arizona Cardinals | State Farm Stadium | |
| Regular season (Week 7) | 10/25/2026 04:25 PM EDT | Green Bay Packers | Detroit Lions | Ford Field | |
| Regular season (Week 8) | 11/01/2026 01:00 PM EST | Minnesota Vikings | Detroit Lions | Ford Field | |
| Regular season (Week 9) | 11/08/2026 01:00 PM EST | Detroit Lions | Miami Dolphins | Hard Rock Stadium | |
| Regular season (Week 10) | 11/15/2026 09:30 AM EST | New England Patriots | Detroit Lions | FC Bayern Munich Stadium | |
| Regular season (Week 11) | 11/22/2026 01:00 PM EST | Tampa Bay Buccaneers | Detroit Lions | Ford Field | |
| Regular season (Week 12) | 11/26/2026 01:00 PM EST | Chicago Bears | Detroit Lions | Ford Field | |
| Regular season (Week 13) | 12/06/2026 01:00 PM EST | Detroit Lions | Atlanta Falcons | Mercedes-Benz Stadium | |
| Regular season (Week 14) | 12/13/2026 01:00 PM EST | Tennessee Titans | Detroit Lions | Ford Field | |
| Regular season (Week 15) | 12/20/2026 08:20 PM EST | Detroit Lions | Minnesota Vikings | U.S. Bank Stadium | |
| Regular season (Week 16) | 12/28/2026 08:15 PM EST | New York Giants | Detroit Lions | Ford Field | |
| Regular season (Week 17) | 01/03/2027 04:25 PM EST | Detroit Lions | Chicago Bears | Soldier Field | |
| Regular season (Week 18) | 01/10/2027 01:00 PM EST | Detroit Lions | Green Bay Packers | Lambeau Field |