NFC North
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) |
Sunday 09/13/2026 1:00 PM EDT |
New Orleans Saints | Detroit Lions | Ford Field | 30 : 31 |
| Regular season (Week 2) |
Thursday 09/17/2026 8:15 PM EDT |
Detroit Lions | Buffalo Bills | Highmark Stadium | 31 : 41 |
| Regular season (Week 3) |
Sunday 09/27/2026 1:00 PM EDT |
New York Jets | Detroit Lions | Ford Field | 24 : 31 |
| Regular season (Week 4) |
Sunday 10/04/2026 8:20 PM EDT |
Detroit Lions | Carolina Panthers | Bank of America Stadium | 26 : 32 |
| Regular season (Week 5) |
Sunday 10/11/2026 4:25 PM EDT |
Detroit Lions | Arizona Cardinals | State Farm Stadium | 45 : 21 |
| Regular season (Week 7) |
Sunday 10/25/2026 4:25 PM EDT |
Green Bay Packers | Detroit Lions | Ford Field | 17 : 20 |
| Regular season (Week 8) |
Sunday 11/01/2026 1:00 PM EST |
Minnesota Vikings | Detroit Lions | Ford Field | |
| Regular season (Week 9) |
Sunday 11/08/2026 1:00 PM EST |
Detroit Lions | Miami Dolphins | Hard Rock Stadium | |
| Regular season (Week 10) |
Sunday 11/15/2026 9:30 AM EST |
New England Patriots | Detroit Lions | FC Bayern Munich Stadium | |
| Regular season (Week 11) |
Sunday 11/22/2026 1:00 PM EST |
Tampa Bay Buccaneers | Detroit Lions | Ford Field | |
| Regular season (Week 12) |
Thursday 11/26/2026 1:00 PM EST |
Chicago Bears | Detroit Lions | Ford Field | |
| Regular season (Week 13) |
Sunday 12/06/2026 1:00 PM EST |
Detroit Lions | Atlanta Falcons | Mercedes-Benz Stadium | |
| Regular season (Week 14) |
Sunday 12/13/2026 1:00 PM EST |
Tennessee Titans | Detroit Lions | Ford Field | |
| Regular season (Week 15) |
Sunday 12/20/2026 8:20 PM EST |
Detroit Lions | Minnesota Vikings | U.S. Bank Stadium | |
| Regular season (Week 16) |
Monday 12/28/2026 8:15 PM EST |
New York Giants | Detroit Lions | Ford Field | |
| Regular season (Week 17) |
Sunday 01/03/2027 4:25 PM EST |
Detroit Lions | Chicago Bears | Soldier Field | |
| Regular season (Week 18) |
Sunday 01/10/2027 1:00 PM EST |
Detroit Lions | Green Bay Packers | Lambeau Field |