AFC East
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) |
Sunday 09/13/2026 1:00 PM EDT |
Buffalo Bills | Houston Texans | Reliant Stadium | 36 : 31 |
| Regular season (Week 2) |
Thursday 09/17/2026 8:15 PM EDT |
Detroit Lions | Buffalo Bills | Highmark Stadium | 31 : 41 |
| Regular season (Week 3) |
Sunday 09/27/2026 1:00 PM EDT |
Los Angeles Chargers | Buffalo Bills | Highmark Stadium | 16 : 24 |
| Regular season (Week 4) |
Sunday 10/04/2026 1:00 PM EDT |
New England Patriots | Buffalo Bills | Highmark Stadium | 29 : 26 |
| Regular season (Week 5) |
Monday 10/12/2026 8:15 PM EDT |
Buffalo Bills | Los Angeles Rams | SoFi Stadium | 37 : 34 |
| Regular season (Week 6) |
Sunday 10/18/2026 4:25 PM EDT |
Buffalo Bills | Las Vegas Raiders | Allegiant Stadium | 33 : 30 |
| Regular season (Week 8) |
Sunday 11/01/2026 1:00 PM EST |
Baltimore Ravens | Buffalo Bills | Highmark Stadium | |
| Regular season (Week 9) |
Monday 11/09/2026 8:15 PM EST |
Buffalo Bills | Minnesota Vikings | U.S. Bank Stadium | |
| Regular season (Week 10) |
Sunday 11/15/2026 1:00 PM EST |
Buffalo Bills | New York Jets | MetLife Stadium | |
| Regular season (Week 11) |
Sunday 11/22/2026 1:00 PM EST |
Miami Dolphins | Buffalo Bills | Highmark Stadium | |
| Regular season (Week 12) |
Thursday 11/26/2026 8:20 PM EST |
Kansas City Chiefs | Buffalo Bills | Highmark Stadium | |
| Regular season (Week 13) |
Sunday 12/06/2026 4:25 PM EST |
Buffalo Bills | New England Patriots | Gillette Stadium | |
| Regular season (Week 14) |
Sunday 12/13/2026 8:20 PM EST |
Buffalo Bills | Green Bay Packers | Lambeau Field | |
| Regular season (Week 15) |
Saturday 12/19/2026 8:20 PM EST |
Chicago Bears | Buffalo Bills | Highmark Stadium | |
| Regular season (Week 16) |
Friday 12/25/2026 4:30 PM EST |
Buffalo Bills | Denver Broncos | Empower Field at Mile High | |
| Regular season (Week 17) |
Sunday 01/03/2027 1:00 PM EST |
Buffalo Bills | Miami Dolphins | Hard Rock Stadium | |
| Regular season (Week 18) |
Sunday 01/10/2027 1:00 PM EST |
New York Jets | Buffalo Bills | Highmark Stadium |