AFC East
| Round | Kickoff | Away | Home | Venue | Result |
|---|---|---|---|---|---|
| Regular season (Week 1) | 09/13/2026 01:00 PM EDT | Buffalo Bills | Houston Texans | Reliant Stadium | |
| Regular season (Week 2) | 09/17/2026 08:15 PM EDT | Detroit Lions | Buffalo Bills | Highmark Stadium | |
| Regular season (Week 3) | 09/27/2026 01:00 PM EDT | Los Angeles Chargers | Buffalo Bills | Highmark Stadium | |
| Regular season (Week 4) | 10/04/2026 01:00 PM EDT | New England Patriots | Buffalo Bills | Highmark Stadium | |
| Regular season (Week 5) | 10/12/2026 08:15 PM EDT | Buffalo Bills | Los Angeles Rams | SoFi Stadium | |
| Regular season (Week 6) | 10/18/2026 04:25 PM EDT | Buffalo Bills | Las Vegas Raiders | Allegiant Stadium | |
| Regular season (Week 8) | 11/01/2026 01:00 PM EST | Baltimore Ravens | Buffalo Bills | Highmark Stadium | |
| Regular season (Week 9) | 11/09/2026 08:15 PM EST | Buffalo Bills | Minnesota Vikings | U.S. Bank Stadium | |
| Regular season (Week 10) | 11/15/2026 01:00 PM EST | Buffalo Bills | New York Jets | MetLife Stadium | |
| Regular season (Week 11) | 11/22/2026 01:00 PM EST | Miami Dolphins | Buffalo Bills | Highmark Stadium | |
| Regular season (Week 12) | 11/26/2026 08:20 PM EST | Kansas City Chiefs | Buffalo Bills | Highmark Stadium | |
| Regular season (Week 13) | 12/06/2026 04:25 PM EST | Buffalo Bills | New England Patriots | Gillette Stadium | |
| Regular season (Week 14) | 12/13/2026 08:20 PM EST | Buffalo Bills | Green Bay Packers | Lambeau Field | |
| Regular season (Week 15) | 12/19/2026 08:20 PM EST | Chicago Bears | Buffalo Bills | Highmark Stadium | |
| Regular season (Week 16) | 12/25/2026 04:30 PM EST | Buffalo Bills | Denver Broncos | Empower Field at Mile High | |
| Regular season (Week 17) | 01/03/2027 01:00 PM EST | Buffalo Bills | Miami Dolphins | Hard Rock Stadium | |
| Regular season (Week 18) | 01/10/2027 01:00 PM EST | New York Jets | Buffalo Bills | Highmark Stadium |